REST Trial Rest logo

Trial Acronym REST Trial
Clinical Area Critical care
Description A pragmatic randomised controlled trial to determine whether Extracorporeal Carbon Dioxide Removal (VV-ECCO2R) and lower tidal volume mechanical ventilation in patients with hypoxaemic respiratory failure improves 90 day mortality
Status Set up
RECRUITMENT


Recruitment duration 01st June 2016 = 30th April 2020 (dependant on internal pilot)
Target Recruitment 1120
TRIAL DESIGN
Trial Design Randomised, allocation concealed, controlled, open, pragmatic clinical and cost effectiveness trial.
Study Aim To deliver a multi-centre clinical trial to determine whether VV-ECCO2R and lower tidal volume mechanical ventilation improves outcomes and is cost-effective, in comparison with standard care in patients who are mechanically ventilated for acute hypoxaemic respiratory failure.
CHIEF INVESTIGATOR (CI)
Chief Investigator Prof Danny McAuley
SPONSOR(s) & FUNDER(s)
Sponsor Belfast Health and Social Care Trust
Funder National Institute for Health Research